Host Daniel Pinchbeck leads a discussion about the current landscape of natural and artificial psychedelic compounds: Ayahuasca, peyote, mushrooms, Iboga, San Pedro, DMT, Salvia, Bufo, 2CB, Ketamine, MDMA, and so on. We review the work of Sasha and Anne Shulgin. We look at chemistry, set and setting, and other factors that influence the effects of these substances. What do we know about their varying capacities from studies at the Imperial College in London, research sponsored by MAPs, and other initiatives? We will look at recent studies of psilocybin, DMT, LSD, ayahuasca, and Ketamine. What are we learning about how chemicals like LSD and DMT affect the brain? What about the dark sides and dangers of psychedelics? Discussion on how they enhance creativity and our capacity for innovative problem-solving.